Harriët Schellekens Selected Research

N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamide

4/2013

Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor.

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Harriët Schellekens Research Topics

Disease

13	Obesity 01/2021 - 01/2010
4	Body Weight (Weight, Body) 01/2022 - 12/2013
3	Feeding and Eating Disorders (Eating Disorder) 01/2020 - 08/2011
3	Cachexia 01/2019 - 05/2018
3	Weight Gain 06/2018 - 12/2013
1	Mental Disorders (Mental Disorder) 02/2021
1	Atrophy 02/2021
1	Overweight 01/2021
1	Neuroinflammatory Diseases 10/2020
1	Cognitive Dysfunction 01/2020
1	Autistic Disorder (Autism) 01/2019
1	Schizophrenia (Dementia Praecox) 01/2019
1	Mood Disorders (Mood Disorder) 01/2019
1	Malnutrition (Nutritional Deficiencies) 09/2018
1	Wasting Syndrome (Wasting Disease) 09/2018
1	Combat Disorders (War Neuroses) 09/2018
1	Chronic Disease (Chronic Diseases) 05/2018
1	Obstructive Lung Diseases (Obstructive Lung Disease) 05/2018
1	Kidney Diseases (Kidney Disease) 05/2018
1	Heart Neoplasms 05/2018
1	Alzheimer Disease (Alzheimer's Disease) 04/2013
1	Food Addiction 01/2013
1	Anorexia Nervosa 08/2011

Drug/Important Bio-Agent (IBA)

6	Ghrelin ReceptorsIBA 01/2019 - 01/2010
6	GhrelinIBA 01/2017 - 01/2010
3	PrebioticsIBA 01/2022 - 02/2015
3	Peptides (Polypeptides)IBA 06/2018 - 08/2011
2	Serotonin (5 Hydroxytryptamine)IBA 02/2021 - 01/2012
2	Hormones (Hormone)IBA 06/2018 - 01/2010
2	5-HT2C Serotonin ReceptorIBA 07/2015 - 01/2012
2	Caseins (Casein)FDA Link 02/2015 - 12/2013
2	LeptinIBA 01/2012 - 08/2011
1	Protein Subunits (Protein Subunit)IBA 02/2021
1	Vitamin A (Retinol)FDA LinkGeneric 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Blood Glucose (Blood Sugar)IBA 01/2021
1	Sulfalene (Longum)IBA 01/2021
1	LipidsIBA 01/2020
1	LigandsIBA 01/2020
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2019
1	SecretagoguesIBA 05/2018
1	QuinolonesIBA 05/2018
1	Growth Hormone (Somatotropin)IBA 05/2018
1	lorcaserinIBA 07/2015
1	SolutionsIBA 02/2015
1	Dietary CalciumIBA 02/2015
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 02/2015
1	Fish OilsIBA 02/2015
1	Fructans (Levans)IBA 02/2015
1	Insulin (Novolin)FDA Link 02/2015
1	Whey ProteinsIBA 12/2013
1	N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA 04/2013
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 04/2013
1	Appetite Depressants (Anorectics)IBA 01/2012
1	Messenger RNA (mRNA)IBA 01/2012
1	serotonin 6 receptorIBA 01/2012
1	5-HT1A Serotonin ReceptorIBA 01/2012
1	RNA (Ribonucleic Acid)IBA 01/2012
1	pyroglutamyl-histidyl-glycineIBA 08/2011

Therapy/Procedure

3	Therapeutics 05/2018 - 01/2012
1	Bariatric Surgery 01/2022
1	Ketogenic Diet 01/2022
1	Caloric Restriction 01/2022
1	Drug Therapy (Chemotherapy) 09/2012